Advantages of Plant Cell Culture for Production of Secondary Metabolites

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Advantages of Plant Cell Culture for Production of Secondary Metabolites

i) The rate of cell growth and biosynthesis in cultures initiated from a very small amount of plant material is quite high and the final product may be produced in a considerably short period of time. This is the contrast to large amounts of mature plant tissues processed to obtain a small quantity of drug.

ii) Plant cell cultures are maintained under controlled environmental and nutritional conditions which ensure the continuous yields of metabolites. On the contrary, continuous decline in the natural habitats due to ecologically disturbed condition may make the availability of source plants uncertain unless they are clonally propagated.

iii) Suspension culture offers a more effective mechanism if incorporating precursors into cells than is found in whole plants.

iv) New routes of synthesis can be recovered from deviant and mutant cell lines which can lead to production of novel compounds not previously found in whole plants.

v) Some cell cultures have the capacity for biotransformation of specific substrates to more valuable products by means of single or multiple –step enzyme activity.

vi) Culture of cell may be more economical for those plants which take long periods to achieve maturity ( E.g. Papaver bracteatum, the source of thebanine , takes two to three seasons to reach maturity).

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